Myocardial Infarction

Myocardial Infarction (MI) is also referred to as a heart attack or coronary thrombosis. It is a condition where a part of the heart muscle suddenly loses blood supply. Typically, a heart attack occurs due to a thrombosis (blood clot) formed within a coronary artery. This obstructs normal blood flow to some part of the heart. If left untreated, myocardial infarction can cause damage to the heart. Besides a severe myocardial infarction can be fatal. There is shortness of breath and profuse sweating. It is essential to seek immediate medical help if you feel that you are suffering a myocardial infarction. Sudden overwhelming stress or laborious exertion or physical activity might bring on a myocardial infarction.

A heart attack is felt as a sudden and severe chest pain that may also travel up and down both arms. The pain felt during myocardial infarction lasts longer than that felt during an angina. In rare cases, a person does not feel any noticeable symptoms and is even unaware that he has suffered a heart attack. Smoking, diabetes, hypertension, high cholesterol and obesity puts a person at increased risk of heart attacks. Heart attacks are more noticed in older men and women, though there is an increasing trend for younger persons to suffer heart disease too. Female sex hormones protect women from heart disease till menopause. Heart ailments and coronary heart disease is sometimes genetic.

An ECG (electrocardiograph) can help trace your heart activity and whether you have suffered a heart attack. A Doppler ultrasound helps examine the heart valves, muscles and blood flow. A coronary angiogram is a special x-ray procedure that tests the severity of the blood vessel block with the help of a dye. The presence of certain enzymes like Troponin-I and Creatinine Kinase (CK) are indicative of a heart attack.

Hospital treatment is esential for a person suffering from a MI. The nature of the treatment hinges on the extent of damage of the heart muscle as well as the blockage of the blood vessels. Medication for dissolving the blood clot is administered. The patient is given drugs to reduce the pain and breathe easier. Beta-blocker drugs may be given to reduce the chances of another heart attacks. ACE Inhibitors may be prescribed to prevent heart failure. Balloon angioplasty may be recommended to improve blood flow to the heart.

Sumatriptan, part of the family of drugs called as triptans is prescribed for the treatment of Migraine and cluster headaches. Migraine headaches are thought to be the result of dilation of blood vessels in the head. Sumatriptan causes constriction of the blood vessels thus relieving Migraine. Triptans are technically abortive migraine medications. However, Sumatriptan does not prevent or reduce the number of migraine attacks. There is another 'triptan' drug which has slightly less side effects than Sumatriptan - Rizatriptan.

Dosage and Administration: Starting dosage may be 25 mg or at the discretion of the physician. However, the Physician might want the patient to take the first dosage at his office to monitor any adverse heart events. Normal dosage is 25 mg to 100 mg or as prescribed by the Physician. Maximum dose in any 24 hours should not exceed 300 mg orally. Do not use Sumatriptan concomitantly with Ergotamine containing preparations.

Safety and efficacy has not been proved for patients over 65 years or for children.

Contraindications: The use of Sumatriptan is contraindicated in hypersensitivity, ischaemic heart disease or previous myocardial infraction, Prinzmetal's angina, coronary vasospasm and controlled hyper tension. Sumatriptan should not be used unless there is a clear diagnosis of Migraine. Before use, exclude underlying cardiac disease especially in patients with risk factors. Chest symptoms may occur which mimic angina but are rarely found to be the result of vasospasm. Vasospasm may result in arrhythmia, ischemia or myocardial infarction. This drug is to be avoided for patients with impaired renal or hepatic functions.

Sumatriptan should not be administered along with ergot type migraine medications, or with MAO inhibitors. Sumatriptan and Ergotamine together can cause prolonged spasm of the blood vessels. It is essential that the use of these two medications should be separated by at least 24 hours.

Side Effects of Sumatriptan: Pain, tingling sensation, heaviness or pressure in the chest region which may be transient. Rarely severe flushing, dizziness, paresthesia, weakness, fatigue, drowsiness may occur. Transient rise in blood pressure may occur.

Sumatriptan, part of the family of drugs called as triptans is prescribed for the treatment of Migraine and cluster headaches. Migraine headaches are thought to be the result of dilation of blood vessels in the head. Sumatriptan causes constriction of the blood vessels thus relieving Migraine. Triptans are technically abortive migraine medications. However, Sumatriptan does not prevent or reduce the number of migraine attacks. There is another 'triptan' drug which has slightly less side effects than Sumatriptan - Rizatriptan.

Dosage and Administration: Starting dosage may be 25 mg or at the discretion of the physician. However, the Physician might want the patient to take the first dosage at his office to monitor any adverse heart events. Normal dosage is 25 mg to 100 mg or as prescribed by the Physician. Maximum dose in any 24 hours should not exceed 300 mg orally. Do not use Sumatriptan concomitantly with Ergotamine containing preparations.

Safety and efficacy has not been proved for patients over 65 years or for children.

Contraindications: The use of Sumatriptan is contraindicated in hypersensitivity, ischaemic heart disease or previous myocardial infraction, Prinzmetal's angina, coronary vasospasm and controlled hyper tension. Sumatriptan should not be used unless there is a clear diagnosis of Migraine. Before use, exclude underlying cardiac disease especially in patients with risk factors. Chest symptoms may occur which mimic angina but are rarely found to be the result of vasospasm. Vasospasm may result in arrhythmia, ischemia or myocardial infarction. This drug is to be avoided for patients with impaired renal or hepatic functions.

Sumatriptan should not be administered along with ergot type migraine medications, or with MAO inhibitors. Sumatriptan and Ergotamine together can cause prolonged spasm of the blood vessels. It is essential that the use of these two medications should be separated by at least 24 hours.

Side Effects of Sumatriptan: Pain, tingling sensation, heaviness or pressure in the chest region which may be transient. Rarely severe flushing, dizziness, paresthesia, weakness, fatigue, drowsiness may occur. Transient rise in blood pressure may occur.